Ese Odo is a Local Government Area (LGA) in Ondo State, Nigeria. It is located in the southern part of the state, along the coast of the Atlantic Ocean. The LGA covers an area of about 1,770 square kilometers and has a population of over 110,000 people.

The biggest towns within this Local Government Area are Arogbo, Igbobini, Agadagba-Obon, and Igbekebo.

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