Isin is a local government area in Kwara State, Nigeria. It is located in the western part of the state and is bordered by Ifelodun, Irepodun, Offa, and Oyun local government areas. The local government area covers an area of approximately 553 square kilometers and has a population of over 90,000 people, according to the 2006 census.

The headquarters of Isin is the town of Owu-Isin, which is a major commercial and administrative center in the local government area. Other notable towns in Isin include Oke-Onigbin, Ijara-Isin, and Osi.

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